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KMID : 0384620090200030125
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Korean Journal of Medical Physics
2009 Volume.20 No. 3 p.125 ~ p.131
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A study of drug content and cell cytotoxicity of paclitaxel-eluting stents coated with various biopolymer
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Kim Dong-Gon
Shin Il-Gyun
Kim Han-Ki
Kim Seong-Hyeon
Lee Ju-Ho
Ki Byoyng-Yun
Nah Jae-Woon
Suh Tae-Suk
Kim Sang-Ho
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Abstract
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In this study, the paclitaxel eluting stent(PES) was prepared by coating a biliary stent with paclitaxel using various biopolymer such as poly(vinyl acetate)(PVAc), poly(lactic-co-glycolic acid)(PLGA), Silicone rubber for restenosis prevention in gastrointestinal disease by a dip-coating method. Drug contents of PES were increased as surface area of stent, concentration and molecular weight of coating polymer increase. In 1H-NMR specta, we know that drug did not change by confirming specific peaks of paclitaxel in PES. As shown in SEM image, PES prepared using various biopolymer is coated clearly and regularly except Silicone rubber coating polymer. In in vitro cell cytotoxicity test, bare stent showed low cytotoxic effect against CT-26 colon carcinoma cell line on 3 day. However, PES coated with PLGA 502H showed the highest cytotoxicity because PLGA 502H is biodegradable polymer and has less molecular weight than other coating polymer. These results suggest that PES coated various biopolymer can be prevented restenosis in gastrointestinal disease.
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KEYWORD
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Drug eluting stent, Paclitaxel, Biopolymer, Restenosis, Drug contents
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